Using Ubuntu 6.10 this article at HowtoForge shows the setup of Virtual Users And Domains With Postfix, Courier And MySQL.
Read it here
The resulting Postfix server is capable of SMTP-AUTH and TLS and quota (quota is not built into Postfix by default, I'll show how to patch your Postfix appropriately). Passwords are stored in encrypted form in the database (most documents I found were dealing with plain text passwords which is a security risk). In addition to that, this tutorial covers the installation of Amavisd, SpamAssassin and ClamAV so that emails will be scanned for spam and viruses.