I use is just plain free software that has no source associated with it (like Skype and Gizmo Project). I took the challenge of wanting to run a 64-bit desktop.
Read it at Colin charles weblog
Excellent, Skype is now installed. Exit the chroot.
sudo ln -s /usr/local/bin/do_dchroot /usr/local/bin/skype
Now, run Skype!
I did this similarly for Gizmo Project. Sound works a charm (thanks to /dev being mounted). The applications seem to run just fine.