Vsftpd is one of the most secure and fastest FTP servers for Linux. Usually vsftpd is configured to work with system users. This document describes how to install a vsftpd server that uses virtual users from a MySQL database instead of real system users. More here
For the administration of the MySQL database you can use web based tools like phpMyAdmin which will also be installed in this howto. phpMyAdmin is a comfortable graphical interface which means you do not have to mess around with the command line.